Hey,
as noted above I already did a clean reinstall of the latest drivers but it did not solve the issue.
I tested the debug mode, but that does not change anything either.
msinfo32 (error reporting full of D2R.exe):
https://pastebin.com/8gpYYd0f
dxdiag:
https://pastebin.com/u1T4Ay75
In this thread (D2R crash after killing Shenk - #30 by Alex-2317) it was already mentioned by blue “Yryadorne” that there seems to be a bug with Shenk (“known issue with the game itself”). Can we expect a fix for this?