Starting game crashes my computer, only game on computer to do this

Starting D2R instantly crashes my computer, it is the only game on my computer to do this. The computer doesn’t return to normal functionality, I have let it sit there for 5 minutes at one point to confirm this. Only way to restore control is by hard restarting my computer.

I have uninstalled and re-installed, OS, Video Card Drivers, all drivers, battle net, and D2R.

system is Intel i9 12900h, 3080 TI, 32GB 4800mhz ram, 1 TB NVMe 4.0.