The game does not save any settings, the game has write permission in Documents, my antivirus is not a problem.
write permission to the file ( Settings_v0.ini ) too?
Apply changes to this folder, subfolders, and files
…
deactivated “OneDrive” ?
In my experience this sort of thing will happen if the folder is managed by backup or cloud sync services like Onedrive.
—> Overwatch not saving settings - #2 by Kershew - Technical Support - Overwatch Forums