It’s for each individual use of the Ctrl key.
So for example setting the hotkey 1.
In the control group section it will have create hotkey 1.
In that section it will say Ctrl + 1.
You would have to click it and then hold the key you want to use as Ctrl, and press 1 to set the hotkey.
It can be done but you’re going to have a lot more time spent on setting up those hotkeys.
Personally, my anchor point for typing is with my pinky over the Ctrl key, especially when gaming but whatever works for you.