When I had appendix surgery like 4 years ago and was basically screwed for about a month or so, I levelled characters in WoW with an xbox controller using erm xpadder I think on my laptop since the laptop had no mouse.
Binding ctrl, shift and alt to L1, L2 and R2, R1 to select target, then using the left stick to move and right for camera, left me with the Dpad, l3, r3, select, start and a,b,x,y buttons free. With the modifiers I had 4 x 9 possible binds.
Was pretty easy for PvE at least and tab targetting so it doesn’t surprise me at all.