If you go to Acherus(the DK place) in the Eastern Kingdoms, you can build up a huge Cryogenic Chamber buff by attacking low level target dummies, allowing you to 1 shot anything with Remorseless Winter. The buff remains only if you stay within the EK region and don’t go through any loading screens etc.
I suppose it can’t be exploited heavily since you’re limited to the Eastern Kingdoms with it, but thought I’d report it just in case.