Not sure why you posted this in the Customer Support forum, General discussion forum or similar would be more fitting.
For myself I use keys around WASD which I use for moving so it might vary if you use ESDF for example:
Q, E, R, T, G, B, V, 1, 2, 3, 4, 5 and variations with SHIFT, ALT, CTRL. For most used abilities I use Q, E, R, 1, 2, 3, 4, 5, sometimes with shift as I find shift to be easiest modifier to use for myself. I also try to bind similar abilities to same keys for each class and spec. For example I use 5 for speed buffs which do not require targeting (eg. Sprint, Burning Rush, Deathâs Advance, paladin charger etc).
I donât use macros for conditionals (shift,alt, ctrl etc) casting as I find it easiest to just assign actions to different bars with different hotkeys.
Best to just experiment it yourself which buttons are easiest to use for you while moving and donât forget your mouse has multiple buttons, too, just less than âMMOâ-mouses.