My gpu settings and all macros (since 2015) disappeared …what is going on/ also cant make new ones
Hello Retributor!
I am really sorry to hear that, recreating all macros might be indeed a little annoying. 
What you can try, is to look up a file that stores the macros for your character. The file is called : macros-cache.txt and it will be located in the WTF folder.
The path to the file, should look like this :
World of Warcraft_retail_\WTF\Account{Account ID}{Realm}{Character Name}
There should be two files, a macros-cache.old and macros-cache.txt
Delete the macros-cache.txt and rename macros-cache.old to macros-cache.txt
Restart the game. Macros should be restored!
Please check the WTF folder as well - as it might have became Read Only for some reason.
- Right click the WTF folder and select Properties
- On the General Tab, uncheck Read-only
- Click OK
- On the Confirm Attribute Changes window, confirm that Apply changes to the folders, sub-folders, and files is selected
- Click OK to apply changes

I will try