Since patch 8.1 or 8.1.5 there is a pretty annoying flickering issue with DX12 and overlay programs. Its happening on the SL beta client too.
A few examples here:
https://i.imgur.com/a7XSUk1.mp4 flickering Icons
https://i.imgur.com/hyrLoKb.mp4 flickering parts of the map
https://i.imgur.com/NuL8uec.mp4 same issue
In my case its caused by RTSS which im using to monitor my CPU/GPU temps and my FPS.
So far i tried pretty much anything, new GPU / different versions of win10 / different drivers / game reinstalls / no addons. The only fix i found so far is to turn off the overlay.