I have two monitors that I use indifferently while playing, one in 4K and the other one in 1080p. I also switch from time to time between my desktop computer and a laptop.
My problem is that I am unable to an UI with Edition Mode that fits in both resolutions, so I have opted to create multiple UI profiles but no matter what, every time I switch computers, or even on the same computer when I move WOW from one monitor to the other, the UI got very messy.
My suggestion is just to allow us to configure UI profiles based on resolutions so that switching monitors or computer makes the game automatically select a profile fitting the new resolution.